Diabetes Risk Calculator

Background

The risk prediction modeling for this calculator was built upon the Diabetes Prevention Program (DPP) randomized trial and study data. This calculator incorporates the known heterogeneity for the DPP interventions on diabetes prevention by baseline weight and blood glucose, and thus provides an individualized predicted risk. The preventive interventions, metformin or lifestyle modification, are assumed to follow the protocol employed in the DPP trial. ^[1,2]

Metformin Protocol: titration to 850mg tablet twice daily (or manageable dose), standard lifestyle recommendations, and annual individual lifestyle session.

Intensive Lifestyle Intervention Protocol: achieve and maintain 7% weight loss through healthy low-calorie and low-fat diet, maintaining moderate-intensity physical activity of ≥150 minutes weekly, and behavioral change curriculum designed to help set and achieve dietary and physical activity goals.

The derivation and validation of this calculator will be posted when published.

References

[1] Diabetes Prevention Program Research Group. The Diabetes Prevention Program. Design and Methods for a Clinical Trial in the Prevention of Type 2 Diabetes. Diabetes Care. 1999;22(4):623-634.

[2] Diabetes Prevention Program Research Group. Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin. The New England Journal of Medicine. 2002;346(6):393-403.

[3] American Diabetes Association Professional Practice Committee. Standards of Care in Diabetes—2024. Diabetes Care 2024;47(Suppl. 1): S1-S321.

Funding

This work was funded by the American Diabetes Association (ADA) Grant 11-22-ICTSPM-18 and does not necessarily represent the official views of the ADA.